Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome  

Alterations in neocortical circuitry in the mouse model of fragile X syndrome, the Fmr1 knock-out mouse, have been found. These alterations include synaptic and network function, and they indicate that neocortical networks are hyperexcitable. Accordingly, these changes could underlie the increased sensitivity to sensory stimuli or even cognitive disabilities in fragile X syndrome patients. The proposed line of study investigating these alterations will provide potential cellular targets for genetic and drug treatments for both fragile X syndrome and autism since both disorders often occur together. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $293,198.00
Project Number 1R01HD056370-01A2
Principal Investigator Gibson, Jay
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of Texas Southwestern Medical Center
State/Country Texas
Web Link 1 Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome | $290,266.00 | 2010 | 5R01HD056370-02
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome (supplement) | $47,848.00 | 2009 | 3R01HD056370-01A2S1