Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The genetics of restricted, repetitive behavior: An inbred mouse model  

In this study, Dr. Lewis and colleagues will develop a mouse model of restricted, repetitive behaviors (RRBs) which will allow them to identify variations in the mouse genome associated with these behaviors. These researchers have previously identified an inbred mouse line that displays both repetitive behaviors (jumping, flipping, and weaving) and restricted behaviors (reduced exploration of the environment). The present research will examine the genetic basis of these behaviors, characterizing the regions of genomic DNA which are associated with these behaviors. This may lead to the identification of gene variants which are involved in the development of RRBs. The examination of genetic variation in a mouse model of RRB should have direct value for clinical genetic studies of ASDs, and aid in understanding the underlying biology of this diagnostic feature of autism. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $60,000.00
Project Number 2533
Principal Investigator Lewis, Mark
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution University of Florida
State/Country Florida
Web Link 1 The genetics of restricted, repetitive behavior: An inbred mouse model (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects The genetics of restricted, repetitive behavior: An inbred mouse model | $60,000.00 | 2010 | 2533
The genetics of restricted, repetitive behavior: An inbred mouse model | $60,000.00 | 2008 | 2533