Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells  

Autism is considered to be among the most common of the serious developmental disabilities, second only to mental retardation. The lifetime per capita incremental societal cost is estimated at $3.2 million. Because the deficits in autism affect human-specific social behaviors, the mechanisms underlying autism will need to be studied in human patients and in cells. The goal of this project is to develop the methods to convert skin cells from patients with autism into neurons and to characterize these neurons using high content screens. These experiments will allow researchers to study the neurons of individuals diagnosed with autism and will lead to a better understanding of the development and differentiation of neurons. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $258,420.00
Project Number 1R21MH087898-01
Principal Investigator Hallmayer, Joachim
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells | $241,503.00 | 2010 | 5R21MH087898-02