Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The CHARGE Study: Childhood Autism Risks from Genetics and the Environment  

Despite a strong influence of genetics, environmental factors are likely to play a causal role for many children with ASD. The proposed project will continue an epidemiologic study of the environmental and genetic causes of autism that was initiated under the University of California-Davis Center for Children's Environmental Health (CCEH). This project, known as the CHARGE (Childhood Autism Risks from Genetics and Environment) Study, is a comprehensive, population-based case-control investigation of underlying causes for autism and triggers of regression. Cases are children with autism and two other groups are included: children with developmental delay and children selected at random from the general population. The proposed study will address the possible role of exposures during the preconceptional, gestational, prenatal, and early childhood periods. Environmental exposures to be studied include infections, assisted reproductive technology, medications, pesticides, brominated flame retardants, and metals. Researchers will also evaluate these environmental factors in conjunction with genes involved in xenobiotic metabolism or identified by gene expression pattern results. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $1,015,021.00
Project Number 5R01ES015359-03
Principal Investigator Hertz-Picciotto, Irva
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3SC. Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 The CHARGE Study: Childhood Autism Risks from Genetics and the Environment (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects The CHARGE Study: Childhood Autism Risks from Genetics and the Environment | $1,005,627.00 | 2010 | 5R01ES015359-04
The CHARGE Study: Childhood Autism Risks from Genetics and the Environment (supplement) | $405,700.00 | 2009 | 3R01ES015359-03S2
The CHARGE Study: Childhood Autism Risks from Genetics and the Environment (supplement) | $1,212,792.00 | 2009 | 3R01ES015359-03S1
The Charge Study: Childhood autism risks from genetics and the environment | $1,014,318.00 | 2008 | R01ES015359-02
The Charge Study: Childhood autism risks from genetics and the environment - Supplemental | $100,000.00 | 2008 | R01ES015359-02S1