Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A systems biology approach to unravel the underlying functional modules of ASD  

This project will investigate autism spectrum disorder (ASD) from the systems biology perspective with the aim of defining the protein networks and functional modules that are relevant to the disease. To achieve this goal, an integrative approach will be used to build an autism protein-protein interaction network that includes autism risk genes, their brain-expressed splice variants, and mutant transcripts of the genes that are disrupted by the breakpoints of genomic deletions and duplications in autistic patients. The results of this study will increase knowledge of the causes of autism and of cognitive development. The discovery of specific pathways, networks, and modules that functionally connect seemingly unrelated autism candidate genes will help researchers understand the molecular mechanisms of ASD development and identify potential therapeutic targets. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $663,063.00
Project Number 1R01HD065288-01
Principal Investigator Iakoucheva, Lilia
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.
Federal or Private? Federal
Institution University of California, San Diego
State/Country California
Web Link 1 A systems biology approach to unravel the underlying functional modules of ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A systems biology approach to unravel the underlying functional modules of ASD | $655,975.00 | 2010 | 5R01HD065288-02