Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance  

The goal of this pilot project is to perform basic science experiments in a mouse model of central nervous system infection with measles virus (MV) to explore the potential link between maternal immune history and neuroinflammation. In preliminary experiments, Dr. Rall has shown that neonatal mice born of mothers that were previously infected with MV had increased expression of pro-inflammatory molecules, including those observed in autistic children. Moreover, the neonates appeared to be immunological tolerant to further infection by MV. This project will further characterize these findings in greater detail to gain insight into the impact of human maternal immunity on the developing immune system of her progeny. This project will help define the role that altered immunity and chronic neuroinflammation play in the etiology of autism spectrum disorders. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $138,915.00
Project Number 2102
Principal Investigator Rall, Glenn
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.
Federal or Private? Private
Institution The Fox Chase Cancer Center
State/Country Pennsylvania
Web Link 1 Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance | $0.00 | 2010 | 2102
Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance | $137,000.00 | 2008 | 2102