Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Atypical late neurodevelopment in autism: A longitudinal MRI and DTI study  

It is critical to continue efforts to understand the brain-basis of autism, how it changes over time, and how it is related to the changing manifestations of the disorder in children and adults. The objective of this research is to understand brain mechanisms as they change from childhood into adulthood in autism and how dynamic brain and clinical phenotype changes are related. This is a case-control longitudinal study of 100 males with autism and 72 matched normal controls using diffusion tensor imaging (DTI) to examine connectivity in the brain. Subjects in the cohort are equally divided into 4 age-bins. At time 1 they are 3-6, 7-11, 12-17, and 18-35 years of age. Follow-up scans will be performed 2, 4, and 6 years later. This research will result in new information important for the development of new treatments and secondary and tertiary preventive interventions. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $503,378.00
Project Number 5R01MH080826-03
Principal Investigator Lainhart, Janet
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Utah
State/Country Utah
Web Link 1 Atypical late neurodevelopment in autism: A longitudinal MRI and DTI study (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Atypical late neurodevelopment in autism: A longitudinal MRI and DTI study | $491,943.00 | 2010 | 5R01MH080826-04
Atypical late neurodevelopment in autism: A longitudinal MRI and DTI study | $507,505.00 | 2008 | R01MH080826-02