Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The impact of autism specific genomic variations on microRNA gene expression profile  

This project hypothesizes that microRNAs (miRNAs) are as important as protein-coding genes in pathways of nervous system development that are involved in autism, and Dr. Scherer's post-doctoral fellow will look for miRNA abnormalities in a systematic way. Previous research in Dr.Scherer's lab has identified autism-associated mutations that are copy number variants (CNVs), and these variants can affect whether there is too much or too little of a particular genetic sequence, including miRNAs. The fellow will use these autism-associated CNVs as a starting point for looking for miRNAs abnormalities. The study will also include a screen of RNA samples prepared from a subset of carefully selected families (mother-father-offspring "trios") using both miRNA and gene expression arrays. Subsequently, he will use functional analyses to confirm the results. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $43,850.00
Project Number 2187
Principal Investigator Scherer, Stephen
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Private
Institution The Hospital for Sick Children
State/Country Canada
Web Link 1 The impact of autism specific genomic variations on microRNA gene expression profile (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects The impact of autism specific genomic variations on microRNA gene expression profile | $0.00 | 2010 | 2187
The impact of autism specific genomic variations on microRNA gene expression profile | $88,000.00 | 2008 | 2187