Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Autism iPSCs for studying function and dysfunction in human neural development  

Autism is a disorder of neural development whose causes are virtually unknown; largely because of this lack of knowledge, there are no consistently successful treatments for this disease. The goal of this project is to shed light on the causes of autism by studying development of the nervous system in a controlled tissue culture environment using sophisticated molecular tools. Cells from the skin of autistic patients will be obtained, using a virtually painless procedure, and then turned into induced pluripotent stem cells (iPSCs) that can develop into every cell type in the body. The development of these cells into nerve cells will be studied in tissue culture, comparing them with cells from unaffected children. This study should help elucidate what goes wrong during brain development in autistic children and help develop a strategy for effective treatment. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $317,520.00
Project Number 1R21MH087925-01
Principal Investigator Loring, Jeanne
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Scripps Research Institute
State/Country California
Web Link 1 Autism iPSCs for studying function and dysfunction in human neural development (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Autism iPSCs for studying function and dysfunction in human neural development | $254,152.00 | 2010 | 5R21MH087925-02