Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Imaging synaptic neurexin-neuroligin complexes by proximity biotinylation: Applications to the molecular pathogenesis of autism  

A major underlying cause of autism is hypothesized to be defects in the development of synapses, which are the points of contact through which brain cells communicate. During development, proteins located on the surfaces of contacting neurons physically interact to regulate the fate and function of the synapse. Dr. Thyagarajan will study the molecular properties of the neurexin-neuroligin complex in live neuronal synapses. They will develop a novel technology to optically image the formation, dynamics, and function of protein complexes at live synapses. They will use this technology to study neurexins and neuroligins during synapse development and determine the effects of autism-linked mutations in these genes on the formation and functions of synapses. Insights from these studies may lead to a better understanding of the underlying biological causes of autism. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $49,000.00
Project Number 4813
Principal Investigator Thyagarajan, Amar
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution Massachusetts Institute of Technology
State/Country Massachusetts
Web Link 1 Imaging synaptic neurexin-neuroligin complexes by proximity biotinylation: Applications to the molecular pathogenesis of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Imaging synaptic neurexin-neuroligin complexes by proximity biotinylation: Applications to the molecular pathogenesis of autism | $0.00 | 2010 | 4813
Imaging synaptic neurexin-neuroligin complexes by proximity biotinylation: Applications to the molecular pathogenesis of autism | $47,500.00 | 2008 | 4813