Project Detail
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Investigating gene-environment interaction in autism: Air pollution X Genetics  

While genetic risk factors are widely implicated in ASDs, the current increase in prevalence is not likely to result from genetic factors alone and it is possible that environmental factors may augment known genetic risks. In this study, researchers seek to examine if air pollution due to traffic, a common environmental exposure, increases risk for ASD. Using data collected as part of the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), researchers will assess the role of traffic related air pollutants in autism risk based on monthly exposure at each child's home during prenatal, perinatal, and postnatal time points. Researchers will also examine genes that process pollutants in the body to determine if they are different in children with and without autism and to see if these genes interact with air pollution to increase autism risk. This work may provide important insight into what causes ASDs and evidence for risk due to a common environmental exposure (traffic-related air pollution). Project Status


Funder National Institutes of Health
Fiscal Year Funding $297,117.00
Project Number 1R21ES019002-01
Principal Investigator McConnell, Rob
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.
Federal or Private? Federal
Institution University of Southern California
State/Country California
Web Link 1 Investigating gene-environment interaction in autism: Air pollution X Genetics (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Investigating gene-environment interaction in autism: Air pollution x genetics | $280,078.00 | 2010 | 5R21ES019002-02