Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Understanding glutamate signaling defects in autism spectrum disorders  

In the present study, Dr. Wang and colleagues will conduct a high-throughput genetic screen in a cohort of autistic patients, looking for DNA sequence variants in 38 genes known to be involved in glutamate neurotransmission. If the hypothesis that glutamate is involved in autism is correct, they expect to find multiple rare sequence variants of these genes in autistic patients compared to a non-autistic control sample. This research may clarify the role of glutamate in autism as well as identify new genetic risk factors and potential drug targets for the treatment and prevention of autism. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $60,000.00
Project Number 2487
Principal Investigator Wang, Tao
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Private
Institution Johns Hopkins University
State/Country Maryland
Web Link 1 Understanding glutamate signaling defects in autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Understanding glutamate signaling defects in autism spectrum disorders | $0.00 | 2010 | 2487
Understanding glutamate signaling defects in autism spectrum disorders | $60,000.00 | 2008 | 2487