Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A molecular genetic study of autism and related phenotypes in extended pedigrees  

Based on reports of a high heritability and a sibling risk ratio > 50, a substantial number of linkage and positional cloning studies have now been conducted to find candidate disease genes for autism. These studies have had limited success, however. Instead of focusing only on sibling pairs, this project will use a strategy involving multigenerational, extended pedigrees with multiple individuals affected with autism, as well as milder but qualitatively similar, genetically-related phenotypes (endophenotypes) in non-autistic relatives. This will be a detailed phenotypic study (including measurement of quantitative and qualitative neuropsychological and behavioral characteristics in autistic individuals and their non-autistic relatives) of twelve extended family pedigrees as part of a whole genome linkage study of autism and related phenotypes. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $483,824.00
Project Number 5R01MH076028-04
Principal Investigator Piven, Joseph
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution University of North Carolina at Chapel Hill
State/Country North Carolina
Web Link 1 A molecular genetic study of autism and related phenotypes in extended pedigrees (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A molecular genetic study of autism and related phenotypes in extended pedigrees | $582,147.00 | 2008 | R01MH076028-03
A molecular genetic study of autism and related phenotypes in extended pedigrees | $582,231.00 | 2010 | 5R01MH076028-05
A molecular genetic study of autism and related phenotypes in extended pedigrees (supplement) | $99,600.00 | 2010 | 3R01MH076028-04S1