Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neuroligin function in vivo: Implications for autism and mental retardation  

Autism spectrum disorder and mental retardation are common, debilitating disorders involving social interaction or cognitive function with clinical overlap in a subset of patients. Recently, loss-of-function mutations in members of the Neuroligin family of trans-synaptic cell adhesion molecules have been implicated in human autism and mental retardation. Mice with genetic alterations of Neuroligin will be electrophysiologically and behaviorally characterized as potential animal models of autism and mental retardation in an effort to better understand the cause and treatment of these debilitating disorders. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $392,500.00
Project Number 1R01MH081164-01A2
Principal Investigator Powell, Craig
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution University of Texas Southwestern Medical Center
State/Country Texas
Web Link 1 Neuroligin function in vivo: Implications for autism and mental retardation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Neuroligin function in vivo: Implications for autism and mental retardation | $392,500.00 | 2010 | 5R01MH081164-02