Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Proteomics in Drosophila to identify autism candidate substrates of UBE3A (supplement)  

Angelman syndrome (AS) is a rare and severe developmental disorder caused by maternal duplications of the region containing the gene UBE3A. AS patients make up 3% of all autism cases. Using the powerful genetic model organism Drosophila (fruit fly), the researchers will identify proteins regulated by UBE3A and investigate the possibility that these proteins are also dysregulated or mutated in some cases of autism. Understanding how increased levels of UBE3A result in an autism phenotype at the molecular level could help researchers better identify and treat autism. This is a supplement to a previously awarded grant with the same title. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $10,000.00
Project Number 3R01NS059902-02S1
Principal Investigator Reiter, Lawrence
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of Tennessee Health Science Center
State/Country Tennessee
Web Link 1 Proteomics in Drosophila to identify autism candidate substrates of UBE3A (supplement) (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Proteomics in Drosophila to identify autism candidate substrates of UBE3A | $319,550.00 | 2009 | 5R01NS059902-02
Proteomics in Drosophila to identify autism candidate substrates of UBE3A | $313,338.00 | 2008 | R01NS059902-01A2
Proteomics in drosophila to identify autism candidate substrates of UBE3A | $316,355.00 | 2010 | 5R01NS059902-03