Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Electrophysiological signatures of language impairment in autism spectrum disorder (supplement)  

This is a supplement to a previously awarded grant with the same title. The clinical profiles of several developmental disorders, including autism spectrum disorders (ASD), involve varying degrees of co-occurring language impairment (LI). The underlying neuronal deficits for LI are numerous and may include deficits in perception, processing, and/or cognition. Current understanding of how a deficit at each or any of these levels might relate to LI is not sufficiently sophisticated to distinguish neuronally-based subtypes of LI. In this study, researchers seek to identify electrophysiological signatures, or endophenotypes, associated with the neural correlates of language impairment in ASD. Specifically, a population of children with autism spectrum disorders (both with and without concomitant LI) will be investigated to find neuronal characteristics associated with autism per se, with LI per se, and with both in combination. If endophenotypes to language impairment can be found, individuals could be sub-typed, or grouped together by the nature of their underlying neuronal deficit, which may aid greatly in addressing the heterogeneity of ASD and in the design of future interventions appropriately targeted to varying ASD subtypes. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $149,432.00
Project Number 3R01DC008871-02S1
Principal Investigator Roberts, Timothy
Received ARRA Funding? Yes
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.
Federal or Private? Federal
Institution Children's Hospital of Philadelphia
State/Country Pennsylvania
Web Link 1 Electrophysiological signatures of language impairment in autism spectrum disorder (supplement) (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Electrophysiological signatures of language impairment in autism spectrum disorder | $357,248.00 | 2010 | 5R01DC008871-04
Electrophysiological signatures of language impairment in autism spectrum disorder | $347,590.00 | 2009 | 5R01DC008871-03
Electrophysiological signatures of language impairment in autism spectrum disorder | $349,288.00 | 2008 | R01DC008871-02
Electrophysiological signatures of language impairment in autism spectrum disorder (supplement) | $55,828.00 | 2010 | 3R01DC008871-03S1