This is an individual National Research Service Award for pre-doctoral research training, which provides support for a promising doctoral candidate to perform dissertation research and training in a scientific health-related field. Autism is a prevalent developmental disorder, characterized by deficits in social interaction and communication. Though twin studies suggest a strong genetic component, genetic mapping studies have failed to identify a single gene underling this complex social disorder. Rather, they have implicated several interacting synaptic proteins that are involved in cell adhesion and cytoskeletal architecture, including the protein ProSAP2. Using cultured cells, this project explores the synaptic mechanisms regulating the dynamics of ProSAP2, a particulariy interesting protein implicated in autism spectrum disorders.