Randy Buckner and his colleagues hypothesize that genetic predisposition to autism occurs when brain development is steered down an abnormal path through the combined influence of dozens — or even hundreds — of common variations, each with a small role. Researchers will attempt to determine the role of such variations in autism by first attempting to understand their role in typical development. They will collect saliva samples from 1,000 typically developing people, as well as data from a recently developed imaging tool called functional connectivity magnetic resonance imaging, or (fcMRI). This tool allows researchers to examine basic properties of brain organization and link differences in these properties to specific genetic variants. Buckner and colleagues have dubbed their effort the Brain Genomics Superstruct Project, as it builds on, or "superstructs," the collective foundation laid by previous work on autism. Because the complex studies linking genetics and brain function will require the effort of many research groups, the researchers plan to share their data collection, which will eventually include 5,000 people. The team will also share their rapid fcMRI protocol, which eases the burden of data acquisition by capturing imaging data in less than 15 minutes per subject.