Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Autistic endophenotypes and their associations to oxytocin and cholesterol  

Clinical, animal, and genetic evidence points to a role for the hormone oxytocin in autism and suggests that oxytocin-related abnormalities may be present in relatives of people with autism. Cholesterol may be similarly linked to ASD. This study will examine the levels of oxytocin and cholesterol in blood samples from 30 families that have at least one member with ASD and compare them to samples from families without autistic family members. Additionally, potential connections between both oxytocin and cholesterol and distinct behavioral and cognitive traits will be explored. Such links between genes and behavioral symptoms are called endophenotypes. Establishing endophenotypes will enable classification of subgroups within autism families that can aid the search for associated genes through molecular genetics studies. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $84,055.00
Project Number 1R03MH085886-01A1
Principal Investigator Silverman, Jeremy
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Mount Sinai School of Medicine
State/Country New York
Web Link 1 Autistic endophenotypes and their associations to oxytocin and cholesterol (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Autistic endophenotypes and their associations to oxytocin and cholesterol | $84,750.00 | 2010 | 5R03MH085886-02