Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Structural brain differences between autistic and typically-developing siblings  

Differences in brain morphology, or the shape and size of the brain, have been identified between children with autism and typically-developing children, though findings have been inconsistent across studies. One potential cause is the variability in brain morphology resulting from the influence of multiple genetic and environmental factors on brain development. A strategy to control for such factors is to compare brain structure between siblings discordant for autism. In this study, researchers will use a brain imaging technique called voxel-based morphometry to examine siblings discordant for autism. Participants will include 27 same-gender sibships between 6-13 years old, consisting of one child with autistic disorder (AU; confirmed with ADI-R and ADOS-G) and one typically-developing sibling (TD). Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $12,030.00
Project Number 5P41RR009784-15
Principal Investigator Steinman, Kyle
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Structural brain differences between autistic and typically-developing siblings (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Structural brain differences between autistic and typically-developing siblings | $2,802.00 | 2008 | P41RR009784-14
Structural brain differences between autistic and typically-developing siblings | $12,333.00 | 2010 | 2P41RR009784-16