Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Cognitive affective and neurochemical processes underlying IS in autism  

This grant provides support for an NIH Autism Center of Excellence (ACE). The overall goal of this ACE is to develop a translational program of research, from gene to behavior, around a clinically important, tractable, and understudied clinical problem in autism: the Insistence on Sameness (IS). At the biochemical level, research suggests that serotonin disturbances may contribute to IS. Rodent studies with serotonin inhibitors will provide a mechanistic understanding of the effects of serotonin receptor activation states. These animal studies will be complemented by a neurobehavioral and functional magnetic resonance imaging (fMRI) study of High IS patients treated with a serotonin inhibitor. The aim of this project is to seek a mechanistic understanding of behavioral features of IS in cognitive neuroscience and biochemical terms. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $377,577.00
Project Number 5P50HD055751-03
Principal Investigator Sweeney, John
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Illinois at Chicago
State/Country Illinois
Web Link 1 ACE Center: Cognitive affective and neurochemical processes underlying IS in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects ACE Center: Cognitive affective and neurochemical processes underlying is in autism | $382,540.00 | 2010 | 5P50HD055751-04