Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Characterization of the transcriptome in an emerging model for social behavior  

The prairie vole is emerging as a premier model organism for understanding the fundamental neurobiology of social behaviors. In contrast to more established rodent models such as mice and rats, voles demonstrate a more diverse range of complex social behaviors. The goal of this research proposal is to advance the development of the prairie vole as a model organism by developing a key genomic resource, a catalog of vole gene sequences. This will enable examination of the nature of social bond formation on a genome-wide scale and may lead to the discovery of novel gene pathways involved in the regulation of complex social behavior such as social bonding. These discoveries could ultimately lead to novel pharmacological interventions to enhance social cognitive function in autism, schizophrenia, or depression. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $426,250.00
Project Number 1RC1GM090950-01
Principal Investigator Thomas, James
Received ARRA Funding? Yes
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Emory University
State/Country Georgia
Web Link 1 Characterization of the transcriptome in an emerging model for social behavior (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Characterization of the transcriptome in an emerging model for social behavior | $426,250.00 | 2010 | 5RC1GM090950-02