Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Multiplexed suspension arrays to investigate newborn and childhood blood samples for potential immune biomarkers of autism  

The principal investigator (PI) is testing the Gestational Neuro-Immuno-Pathology (GENIP) model, which proposes an etiologic role for autoimmune or cross-reactive antibodies maternally transferred across the placenta, when the fetal blood-brain barrier is more permeable to IgG transfer. The PI is developing a microbead suspension array (MSA) to assay dried blood spots (DBS) from newborns. Nerve tissue antigen-specific IgG antibodies were measured with the MSA assay. The study found that higher levels of nerve tissue antigen-specific IgG antibodies in newborn DBS were associated with a reduced risk of autism spectrum disorders (ASD) compared to matched controls. Project Status
ONGOING

2009

Funder Department of Defense
Fiscal Year Funding $0.00
Project Number AS073186
Principal Investigator Vogt, Robert
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD by 2014. IACC Recommended Budget: $33,300,000 over 5 years.
Federal or Private? Federal
Institution Centers for Disease Control and Prevention (CDC)
State/Country Georgia
Web Link 1 Multiplexed suspension arrays to investigate newborn and childhood blood samples for potential immune biomarkers of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Multiplexed suspension arrays to investigate newborn and childhood blood samples for potential immune biomarkers of autism | $0.00 | 2010 | AS073186