Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions  

Dr. Parada and his colleagues have generated mouse models by mutating particular genes linked to autism spectrum disorder. In one such model, the researchers deleted the PTEN gene in a subset of neurons in the cortex and hippocampus of the brain. The altered mice display deficits which are seen in people with autism. The brains of the mice also have structural abnormalities, including enlarged neurons, that are caused by the cells harboring the PTEN mutation, and could be the root of the behavior deficits. Parada and his colleagues plan to determine whether other genes in the PTEN signaling pathway also have a role in autism. They also aim to investigate the role of PTEN and other genes of interest in specific cell populations and anatomic regions of the brain, to try to narrow down the regions involved in these behavioral disorders. The mouse models will allow the researchers to disrupt autism-linked genes in specific regions of the brain and look for resulting changes in behavior and brain morphology — studies that could not be carried out in people. Project Status
NEW

2009

Funder Simons Foundation
Fiscal Year Funding $100,000.00
Project Number 137078
Principal Investigator Parada, Luis
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Private
Institution University of Texas Southwestern Medical Center
State/Country Texas
Web Link 1 Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions | $400,000.00 | 2010 | 137078