Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Characterization of the pathological and biochemical markers that correlate to the clinical features of autism  

The goal of this research is to identify morphological markers of deregulation of neuronal metabolism in autism, with a special emphasis on early a) expression of markers of oxidative stress, b) enhanced amyloid precursor protein (APP) processing and abnormal Aβ accumulation in neurons, c) deposition of excessive amount of products of distorted cell metabolism in lipofuscin, and d) activation of inflammatory response to neuronal damage and to detect patterns of pathological changes in the brain. The brains of autistic subjects and control subjects are obtained from the postmortem tissue bank from the Autism Tissue Program. Project Status
ONGOING

2009

Funder Department of Defense
Fiscal Year Funding $0.00
Project Number AS073224
Principal Investigator Wegiel, Jerzy
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Research Foundation for Mental Hygiene, Inc.
State/Country New York
Web Link 1 Characterization of the pathological and biochemical markers that correlate to the clinical features of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Characterization of the pathological and biochemical markers that correlate to the clinical features of autism | $0.00 | 2010 | AS073224P2
Characterization of the pathological and biochemical markers that correlate to the clinical features of autism | $0.00 | 2010 | AS073224
Characterization of the pathological and biochemical markers that correlate to the clinical features of autism | $0.00 | 2010 | AS073224P1
Characterization of the pathological and biochemical markers that correlate to the clinical features of autism | $0.00 | 2009 | AS073224P1
Characterization of the pathological and biochemical markers that correlate to the clinical features of autism | $0.00 | 2009 | AS073224P2