Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A genome-wide search for autism genes in the Simons Simplex Collection  

Dr. State is heading up a large, multi-institutional study that aims to scour the genetic data in the Simons Simplex Collection for autism-related genes. Evidence suggests that some of the genetic defects in the affected individuals are likely to be spontaneous and non-inherited. As these types of genetic changes are rare in unaffected individuals, State and colleagues plan to focus on identifying these spontaneous variants as a clue to the location of autism-related genes. They plan to then sequence genes within these promising segments in an effort to identify additional mutations that can help confirm their relationship to autism. The researchers then plan to further test any associations they identify in an independent sample of families. State and colleagues have hypothesized that many different types of variations in the genome will ultimately be found to contribute to autism spectrum disorders. Project Status
ONGOING

2009

Funder Simons Foundation
Fiscal Year Funding $3,862,333.48
Project Number 124827
Principal Investigator State, Matthew
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Private
Institution Yale University
State/Country Connecticut
Web Link 1 A genome-wide search for autism genes in the Simons Simplex Collection (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A genome-wide search for autism genes in the Simons Simplex Collection | $3,896,750.15 | 2010 | 124827
A genome-wide search for autism genes in the Simons Simplex Collection | $2,896,750.11 | 2008 | Project number unavailable