Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Validation study of atypical dynamic pupillary light reflex as a biomarker for autism  

This research will evaluate dynamic pupillary light reflex (PLR) as a potential biomarker for autism. PLR refers to the involuntary response whereby the pupil size changes in response to a short flash of light, and it can serve as a simple objective measure of neurological functions. Preliminary studies revealed that individuals with autism showed significantly longer constriction latencies and smaller constriction amplitudes in their PLR responses. The proposed research will validate these preliminary results in a large heterogeneous group of participants and will clarify whether the atypical PLR parameters are specific to autism spectrum disorder (ASD) or are associated with autonomic nervous system dysfunction in general. These studies will allow for further evaluation of the specificity and generalizability of PLR as a potential biomarker for ASD. The PLR testing procedure is low-cost, non-invasive, objective, and has the potential to be implemented for very young children. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $204,525.00
Current Award Period 2009-2011
Project Number 5R21NS070299-02
Principal Investigator Yao, Gang; Miles, Judith; Christ, Shawn
Received ARRA Funding? Yes
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Subcategory Early Signs and Biomarkers
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.
Federal or Private? Federal
Institution University of Missouri
State/Country Missouri
Web Link 1 Validation study of atypical dynamic pupillary light reflex as a biomarker for autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Validation study of atypical dynamic pupillary light reflex as a biomarker for autism | $204,525.00 | 2009 | 1R21NS070299-01