Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for idiopathic ASD  

Down syndrome is the most common genetic disorder associated with neurobehavioral problems, and many children with Down syndrome have clinically significant behavioral problems, including autism spectrum disorders (ASD). Preliminary research from Dr. Kaufmann's lab has shown that children with both Down syndrome and ASD have a unique profile of autistic core symptoms, including severe stereotypies (repetitive movements) which are distinct from more common movement disorders associated with Down syndrome. The present study will test and further confirm the hypothesis that the diagnosis of Down syndrome plus ASD is associated with both a unique behavioral profile and distinctive genetic characteristics. 70 boys with Down syndrome, with and without ASD, will be recruited for this study. Subjects will be evaluated for behavioral problems, including stereotypies and developmental regression, using methods of analysis which have not yet been applied to studying behavior in Down syndrome. This research may lead to improved diagnoses and treatment of Down syndrome plus ASD, and provide insight into various behavioral aspects of ASDs. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $60,000.00
Current Award Period 2008-2011
Project Number 2622
Principal Investigator Kaufmann, Walter
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Subcategory Intermediate Phenotypes/Subgroups
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.
Federal or Private? Private
Institution Kennedy Krieger Institute
State/Country Maryland
Web Link 1 Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for idiopathic ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for idiopathic ASD | $60,000.00 | 2009 | 2622
Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for idiopathic ASD | $60,000.00 | 2008 | 2622