Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls  

Several structural brain abnormalities have been associated with autism, but none have been consistently replicated, and no single abnormality is seen in all persons with autism. A potential factor contributing to these inconsistencies is the inherent difficulty in controlling for genetic and environmental variables that influence brain development. To overcome this difficulty, Dr. Barnea-Goraly will compare brain structure in siblings discordant for autism (sibling pairs in which one has autism and the other does not). This design minimizes genetic and environmental differences that could influence brain morphology. The study will use an innovative analysis of brain-surface complexity in individuals with autism, their non-autistic siblings, and in control subjects to examine the relationship between brain structure and autism. The study will also assess brain-surface complexity in very young subjects with autism (23-43 months of age) as compared to age- and gender-matched control subjects. This very young population will allow investigation of brain structure at the earliest ages in which autism diagnosis is possible. In addition, measures of brain-surface complexity will be compared to behavioral features of subjects with autism. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $100,000.00
Current Award Period 2008-2010
Project Number 2319
Principal Investigator Barnea-Goraly, Naama
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Neural Systems
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution Stanford University
State/Country California
Web Link 1 Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls | $0.00 | 2009 | 2319
Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls | $100,000.00 | 2008 | 2319