Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity  

Among the genetic mutations associated with a susceptibility to autism are those found in two families of genes, the neurexins and the neuroligins. Neurexins are present in the presynaptic cell (the cell sending information), and neuroligins are present on the postsynaptic cell (the cell receiving information). Because neurexins and neuroligins recognize and bind each other very specifically, they are thought to be involved in the formation and maintenance of synapses and to be involved in the specification of particular synaptic connections between particular cells of the brain. In this study, Dr. Comoletti and colleagues will study the molecular basis of the interaction between neurexins and neuroligins: by mutating various regions of each gene, they will determine which parts of the encoded proteins are important for these physical interactions to occur. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $60,000.00
Current Award Period 2009-2011
Project Number 2617
Principal Investigator Comoletti, Davide
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution University of California, San Diego
State/Country California
Web Link 1 Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity | $60,000.00 | 2009 | 2617
Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity | $60,000.00 | 2008 | 2617