Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Analysis of brain microstructure in autism using novel diffusion MRI approaches  

There is increasing evidence that brain regions of autistic individuals have altered neural connectivity between different brain regions. Preliminary work has shown that autistic brains tend to have changes in the structure and anatomy of the white matter tracts that carry neural information between brain regions. The methods commonly used to visualize the anatomy of white matter, diffusion tensor magnetic resonance imaging (MRI) and diffusion-tensor tracking, do not provide a level of microscopic detail which would allow researchers to determine the underlying biological causes of the structural abnormalities observed in white matter. In the present study, Dr. Conturo and colleagues will develop new diffusion MRI techniques which will allow them to examine the microscopic structure of white matter tracts. They will combine existing diffusion MRI methods with novel computational approaches aimed at determining the cellular basis of white matter abnormalities, and apply these new methods to examining the brains of individuals with autism. This research may help to define the underlying cellular disturbances which result in abnormal white matter tracts in autism, as well as provide new diagnostic tools for neurodevelopmental disorders. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $0.00
Current Award Period 2008-2010
Project Number 3799
Principal Investigator Conturo, Thomas
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Computational Science
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution Washington University School of Medicine
State/Country Missouri
Web Link 1 Analysis of brain microstructure in autism using novel diffusion MRI approaches (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Analysis of brain microstructure in autism using novel diffusion MRI approaches | $59,992.00 | 2009 | 3799
Analysis of brain microstructure in autism using novel diffusion MRI approaches | $60,000.00 | 2008 | 3799