Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Are neuronal defects in the cerebral cortex linked to autism?  

During development, neurons produced at a similar time from progenitor cells migrate and occupy similar positions in the cerebral cortex. They are layered horizontally and then connect vertically into columns. In this way, neurons that transmit excitatory messages connect with those that transmit inhibitory messages, forming local communication networks. In children with autism, these neural columns are more narrow and dense than in normally-developing children. The researchers hypothesize that these abnormalities are linked to autism, possibly due to an imbalance between excitatory and inhibitory neurons, or to impairments in their connections. They will explore this hypothesis in mice with fragile X syndrome (a genetically caused form of autism). Using two-photon cellular imaging, they will follow migrating neurons into the cerebral cortex and map their connections using electrophysiology recordings. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $28,334.00
Current Award Period 2007-2010
Project Number 5274
Principal Investigator Shi, Song-Hai
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Neural Systems
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution Memorial Sloan-Kettering Cancer Center
State/Country New York
Web Link 1 Are neuronal defects in the cerebral cortex linked to autism? (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Are neuronal defects in the cerebral cortex linked to autism? | $0.00 | 2009 | 5274
Are neuronal defects in the cerebral cortex linked to autism? | $33,000.00 | 2008 | 5274