Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

RNA-Seq studies of gene expression in cells and networks in FI and ACC in autism  

This research will help understanding of the cellular bases of autism by using a new technology, RNA-Seq, to determine differences in gene expression in autopsy brains of subjects with well described autism versus age and sex matched neurotypical individuals. In a previous study, two specific cortical areas involved in self-awareness and social reciprocity, which are abnormal in autism, were investigated, and findings indicated increased expression in a network of genes related to inflammation in autism group A, whereas the remaining cases, autism group B, have increased expression in a network of genes related to synapses. This study will use laser micro-dissection to investigate gene expression in specific neuronal and non-neuronal populations in the cortical areas of interest in the autism-A, autism-B, and control groups. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $551,118.00
Current Award Period 2009-2011
Project Number 5R01MH089406-02
Principal Investigator Allman, John; Wold, Barbara
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Neuropathology
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution California Institute of Technology
State/Country California
Web Link 1 RNA-Seq studies of gene expression in cells and networks in FI and ACC in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects RNA-Seq studies of gene expression in cells and networks in FI and ACC in autism | $564,301.00 | 2009 | 1R01MH089406-01