Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Diffusion tensor MRI + histopathology of brain microstructure + fiber pathways  

This grant provides support for an NIH Autism Center of Excellence (ACE). A growing body of evidence suggests that autism is a disorder of brain connectivity. This project will study the anatomic connectivity and microstructural abnormalities of the brain in autism by using diffusion tensor magnetic resonance imaging (DT-MRI or DTI) and diffusion tensor tracking (DTT). Microscopic structural changes in white matter pathways and the associated gray matter regions in 40 individually-matched pairs of adults (age18-35 yrs) and 30 individually-matched pairs of children (age 6-11 yrs) with and without autism will be measured. Those results will be correlated with behavioral measures to identify phenotypic links with abnormalities in the brain microstructure. The results of this project will provide a comprehensive understanding of brain microstructure and histopathology and will also provide critical insight into the structural outcome of the early disturbances in brain growth in autism. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $25.00
Current Award Period 2007-2012
Project Number 5P50HD055748-04
Principal Investigator Conturo, Thomas
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Neuropathology
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Pittsburgh
State/Country Pennsylvania
Web Link 1 ACE Center: Diffusion tensor MRI + histopathology of brain microstructure + fiber pathways (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects ACE Center: Diffusion tensor MRI + histopathology of brain microstructure + fiber pathways | $12.00 | 2009 | 5P50HD055748-03
ACE Center: Diffusion tensor MRI + histopathology of brain microstructure + fiber pathways (supplement) | $2.00 | 2009 | 3P50HD055748-03S1