Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses  

This is an individual National Research Service Award for post-doctoral research training, which provides support for promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields. Synaptic plasticity is believed to underlie learning and memory, the basis for behavior. Neuroligins are synaptic proteins, and mutations in the genes coding for these proteins and their binding partners have been found in autism spectrum disorders. These disorders are characterized by impaired social interactions, and several mice that either lack the neuroligin 1 gene or have a specific mutation added that is found in autistic patients are known to have impaired social behavior. Recent studies have found mutations in many activity-dependent genes in autistic patients, and it is possible that the neuroligins are important in activity-dependent synaptic plasticity. The objective of this study is to investigate the role of neuroligins in synaptic plasticity at excitatory and inhibitory synapses in order to better understand the role of neuroligins in physiology and pathophysiology. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $59,918.00
Current Award Period 2009-2011
Project Number 5F32MH086224-02
Principal Investigator Engelman, Holly
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Albert Einstein College of Medicine of Yeshiva University
State/Country New York
Web Link 1 Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses | $57,194.00 | 2009 | 1F32MH086224-01