Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Analysis of Fgf17 roles and regulation in mammalian forebrain development  

This is an individual National Research Service Award for post-doctoral research training, which provides support for promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields. Fibroblast growth factors (Fgfs) have been implicated in developmental processes that contribute to the etiologies of autism and related psychiatric disorders. Fgf17, one of four expressed in the vertebrate rostral forebrain signaling center (RFSC), is required for normal development of the dorsal frontal cortex. Mice in which the Fgf17 gene has been deleted exhibit cortical patterning defects, as well as behavior and cognition phenotypes that mirror aspects of autism spectrum disorders. The specific roles of Fgf17 during brain development and their effects on postnatal brain functions are not yet known. The proposed studies use mouse genetics to analyze the roles and regulation of Fgf17 in the developing forebrain, including identifying some of the key molecules involved and how these molecules impact postnatal cognition and behavior. Together, these analyses will help to identify developmental processes and regulatory factors that contribute to the etiologies of autism and related psychiatric disorders. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $52,154.00
Current Award Period 2008-2010
Project Number 5F32MH081431-02
Principal Investigator Hoch, Renee
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of California, San Francisco
State/Country California
Web Link 1 Analysis of Fgf17 roles and regulation in mammalian forebrain development (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Analysis of FGF17 roles and regulation in mammalian forebrain development | $51,886.00 | 2008 | F32MH081431-01A2