Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A systems biology approach to unravel the underlying functional modules of ASD  

This project will investigate autism spectrum disorder (ASD) from the systems biology perspective with the aim of defining the protein networks and functional modules that are relevant to the disease. To achieve this goal, an integrative approach will be used to build an autism protein-protein interaction network that includes autism risk genes, their brain-expressed splice variants, and mutant transcripts of the genes that are disrupted by the breakpoints of genomic deletions and duplications in autistic patients. The results of this study will increase knowledge of the causes of autism and of cognitive development. The discovery of specific pathways, networks, and modules that functionally connect seemingly unrelated autism candidate genes will help researchers understand the molecular mechanisms of ASD development and identify potential therapeutic targets. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $655,975.00
Current Award Period 2009-2011
Project Number 5R01HD065288-02
Principal Investigator Iakoucheva, Lilia
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of California, San Diego
State/Country California
Web Link 1 A systems biology approach to unravel the underlying functional modules of ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A systems biology approach to unravel the underlying functional modules of ASD | $663,063.00 | 2009 | 1R01HD065288-01