Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

GABA(A) receptor modulation via the beta subunit  

GABA(A) receptors convey the majority of synaptic inhibition in the central nervous system. Synaptic inhibition is the process by which excitation of a presynaptic interneuron prevents the excitation of a postsynaptic principal neuron. GABA(A) receptors also are important therapeutic targets for depressant medications (i.e., benzodiazepines) and general anesthetics. Mutations in GABA(A) receptor genes have been linked to familial epilepsies, schizophrenia, and autism. However, it is not known how these chemicals modulate receptor function or how these mutations contribute to receptor dysfunction or disease pathology at the molecular level. The goals of this project are to characterize a new binding site on the receptor and to better understand the molecular events that underpin the activation and modulation of fast inhibitory neurotransmission. The results may aid in understanding how inherited mutations in GABA(A) receptor genes contribute to the pathogenesis of diseases such as autism, and the characterization of the new binding site may provide a new target for treating neuropsychiatric diseases. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $226,499.00
Current Award Period 2006-2012
Project Number 5R01GM073959-05
Principal Investigator Jenkins, Andrew
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Emory University
State/Country Georgia
Web Link 1 GABA(A) receptor modulation via the beta subunit (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects GABA(A) receptor modulation via the beta subunit | $228,787.00 | 2009 | 5R01GM073959-04
Gaba(A) receptor modulation via the beta subunit | $228,787.00 | 2008 | R01GM073959-03