Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Engrailed genes and cerebellum morphology, spatial gene expression and circuitry  

The cerebellum integrates information such as the position, speed, and force at which the limbs and body are moving, all of which are necessary to carry out smooth, coordinated movements. It also is implicated in cognitive functions like language. Mice with mutations in Engrailed (En) genes display morphological defects in the cerebellum and topographic disruptions of afferent pathways as well as deficits in social interactions. These animal models will be studied to get a better understanding of how En1/2 regulate cerebellum development. A better understanding of how mutations in the Engrailed (En) genes result in a range of morphological cerebellum defects as well as disruptions of neural circuits should provide new principals to aid in the interpretation of human diseases which involve reduction in the size of the cerebellum, as well as diseases such as autism spectrum disorder (ASD) where there are more subtle structural alterations but could nevertheless have profound dysfunction of neural circuits. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $474,750.00
Current Award Period 2009-2014
Project Number 5R01MH085726-02
Principal Investigator Joyner, Alexandra
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Memorial Sloan-Kettering Cancer Center
State/Country New York
Web Link 1 Engrailed genes and cerebellum morphology, spatial gene expression and circuitry (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Engrailed genes and cerebellum morphology, spatial gene expression and circuitry | $474,750.00 | 2009 | 1R01MH085726-01