Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Neuroimaging studies of connectivity in ASD  

This grant provides support for an NIH Autism Center of Excellence (ACE). On the basis of structural magnetic resonance imaging (sMRI) and head circumference studies, it is now well established that brain size is often enlarged in autism. Most evidence also indicates that white matter volume (consisting mostly of axons in the brain) is disproportionately enlarged compared to gray matter volume, and new data from functional MRI (fMRI) and diffusion tensor imaging (DTI) studies of ASDs have shown alterations in "functional connectivity" among people with ASDs. This study proposes to characterize cerebral white matter abnormalities in the ASDs, both in terms of alteration in its total volume using sMRI and through the use of DTI. This anatomical information will be correlated with fMRI functional connectivity data to look at the relationship between volume and quantitative and dynamic measures of functional connectivity. Project Status


Funder National Institutes of Health
Fiscal Year Funding $330,130.00
Current Award Period 2008-2013
Project Number 5P50MH081756-03
Principal Investigator Staib, Lawrence
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Neural Systems
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Yale University
State/Country Connecticut
Web Link 1 ACE Center: Neuroimaging studies of connectivity in ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects ACE Center: Neuroimaging studies of connectivity in ASD | $337,540.00 | 2009 | 5P50MH081756-02