Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Imaging signal transduction in single dendritic spines  

Many forms of mental retardation and autism are caused by abnormal intracellular signaling cascades involving proteins in the Rho family. The shape and function of synapses are regulated by signaling mediated by Rho proteins. This project will develop a novel cellular imaging technique to measure the activity of Rho proteins in single synapses, leading to a fuller understanding of how Rho activity helps to control the function of synapses. This study will illuminate some of the molecular mechanisms of synaptic plasticity and will provide insights into diseases caused by mutations in Rho signaling pathways, such as mental retardation and autism. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $386,100.00
Current Award Period 2009-2014
Project Number 5R01NS068410-02
Principal Investigator Yasuda, Ryohei
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Duke University
State/Country North Carolina
Web Link 1 Imaging signal transduction in single dendritic spines (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Imaging signal transduction in single dendritic spines | $390,000.00 | 2009 | 1R01NS068410-01