Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

High-throughput DNA sequencing method for probing the connectivity of neural circuits at single-neuron resolution  

The brain is an extremely complex network, consisting of billions of neurons connected by trillions of synapses. The details of these connections-which neurons form synaptic connections with which other neurons-are crucial in determining brain function. Malformation of these connections during prenatal and early postnatal development can lead to mental retardation, autism or schizophrenia; loss of specific connections later in life is associated with neurodegenerative diseases such as Alzheimer's. Researchers in this study are developing a method for identifying these complex neuronal connections in animal models of disease. Using high-throughput DNA sequencing, researchers will probe the connectivity of neural circuits at single-neuron resolution. This novel, efficient method for determining the brain's wiring diagram could transform neuroscience research and have a profound impact on understanding the causes of neurodevelopmental and neurodegenerative diseases. Project Status
NEW

2010

Funder National Institutes of Health
Fiscal Year Funding $435,000.00
Current Award Period 2010-2015
Project Number 1R01NS073129-01
Principal Investigator Zador, Anthony
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Cold Spring Harbor Laboratory
State/Country New York
Web Link 1 High-throughput DNA sequencing method for probing the connectivity of neural circuits at single-neuron resolution (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Not available at this time. This functionality is experimental.