Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A role for immune molecules in cortical connectivity: Potential implications for autism  

The study will use molecular biology and biochemical techniques to alter the function of MHCI and MEF2 in brain cells to probe the molecular pathway underlying their function. By defining the relationship between these two proteins with respect to synapse formation, this study will increase understanding of how the immune system could alter connections in the developing brain to give rise to neurodevelopmental disorders. Results from the study could identify novel drug targets for treating diseases that are influenced by immune dysregulation, such as autism. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $28,000.00
Current Award Period 2009-2011
Project Number 6339
Principal Investigator Elmer, Bradford
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Immune/Metabolic Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)
Federal or Private? Private
Institution University of California, Davis
State/Country California
Web Link 1 A role for immune molecules in cortical connectivity: Potential implications for autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A role for immune molecules in cortical connectivity: Potential implications for autism | $28,000.00 | 2009 | 4934