Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A non-human primate autism model based on maternal immune activation  

Based on epidemiological evidence that viral infection of pregnant women can strongly increase the risk for autism in their offspring, a mouse model of maternal immune activation has been established. Pregnant mice are given a respiratory infection at midgestation, and the offspring display a series of behavioral abnormalities consistent with those seen in autism, including deficits in social interaction and investigation of novel objects, as well as increased anxiety under mildly stressful conditions. Moreover, these offspring exhibit a specific type of neuropathology that is often seen in autism: spatially localized deficit of Purkinje cells in the cerebellum. Now that the mouse model has shown behavioral and histological abnormalities consistent with those found in autism, it is important to extend this work to primates. These animals possess a behavioral repertoire, such as the expression and interpretation of facial expressions, which is very homologous with human social behavior. Non-human primates therefore provide a sensitive indicator of impairments in social behavior and communication. A valid primate model of autism would also provide a unique resource for evaluating therapeutic interventions. Project Status
NEW

2010

Funder National Institutes of Health
Fiscal Year Funding $114,105.00
Current Award Period 2010-2011
Project Number 2P51RR000169-49
Principal Investigator Patterson, Paul
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Immune/Metabolic Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 A non-human primate autism model based on maternal immune activation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A non-human primate autism model based on maternal immune activation | $106,670.00 | 2009 | 5P51RR000169-48
A non-human primate autism model based on maternal immune activation | $81,333.00 | 2008 | P51RR000169-47