Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

BDNF and the restoration of spine plasticity with autism spectrum disorders  

This project will test if mice with autistic behavioral traits have impairments to the same biological mechanisms underlying learning and memory as occur in other syndromes of cognitive dysfunction. Researchers will test whether well-tolerated drugs causing the brain to increase production of brain-derived neurotrophic factor (BDNF) can normalize these biological mechanisms and behavior in these animals. This includes tests to determine if these drugs correct behavioral abnormalities in the mouse model of fragile X mental retardation syndrome and in a second mouse strain with features of autism. Results from this study could highlight BDNF as an effective therapeutic target for correcting impairments in learning and memory in autism and fragile X. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $564,519.00
Current Award Period 2009-2011
Project Number 5P01NS045260-07
Principal Investigator Gall, Christine
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of California, Irvine
State/Country California
Web Link 1 BDNF and the restoration of spine plasticity with autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects BDNF and the restoration of spine plasticity with autism spectrum disorders | $571,019.00 | 2009 | 2P01NS045260-06A1