Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome  

Alterations in neocortical circuitry in the mouse model of fragile X syndrome, the Fmr1 knock-out mouse, have been found. These alterations include synaptic and network function, and they indicate that neocortical networks are hyperexcitable. Accordingly, these changes could underlie the increased sensitivity to sensory stimuli or even cognitive disabilities in fragile X syndrome patients. The proposed line of study investigating these alterations will provide potential cellular targets for genetic and drug treatments for both fragile X syndrome and autism since both disorders often occur together. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $290,266.00
Current Award Period 2009-2013
Project Number 5R01HD056370-02
Principal Investigator Gibson, Jay
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of Texas Southwestern Medical Center
State/Country Texas
Web Link 1 Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome | $293,198.00 | 2009 | 1R01HD056370-01A2
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome (supplement) | $47,848.00 | 2009 | 3R01HD056370-01A2S1