Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A longitudinal MRI study of brain development in fragile X syndrome  

The proposed research will conduct a magnetic resonance imaging (MRI) study of very early brain and behavior development at 6, 12, and 24 months in infants with fragile X syndrome (FXS) using MRI and diffusion tensor imaging (DTI). The study will examine how the path and growth of brain development in infants with FXS compares to early brain development in infants at high-risk for autism [who later develop autism spectrum disorder (ASD)] as well as typically developing infants. It will also assess the trajectory of early post-natal brain overgrowth in FXS, as measured on MRI and DTI, and its potential relationship to clinical features, particularly those features characteristic of ASD. This study has the potential to distinguish specific behavioral, genetic, and neurobiological features that characterize infants with FXS in comparison with infants at high-risk for autism and those with typical development. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $617,080.00
Current Award Period 2009-2011
Project Number 5R01HD059854-02
Principal Investigator Hazlett, Heather
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Developmental Trajectory
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of North Carolina at Chapel Hill
State/Country North Carolina
Web Link 1 A longitudinal MRI study of brain development in fragile X syndrome (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A longitudinal MRI study of brain development in fragile X syndrome | $622,099.00 | 2009 | 1R01HD059854-01A1