Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Translation regulation in hippocampal LTP and LTD  

The prevalence of autism spectrum disorders among children with fragile X syndrome and tuberous sclerosis is estimated to be 15-30% and 25-60%, respectively. The purpose of this research is to identify the biochemical mechanisms responsible for initiating protein synthesis during synaptic plasticity (important to learning and memory), and whether these mechanisms are altered and can be reversed in mouse models of fragile X syndrome and tuberous sclerosis. Pharmacological and genetic approaches will be used to try to reverse the alterations in synaptic plasticity, with the potential to identify new therapeutic targets to treat fragile X syndrome and tuberous sclerosis. Project Status


Funder National Institutes of Health
Fiscal Year Funding $372,141.00
Current Award Period 2009-2012
Project Number 5R01NS047384-07
Principal Investigator Klann, Eric
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution New York University
State/Country New York
Web Link 1 Translation regulation in hippocampal LTP and LTD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Translation regulation in hippocampal LTP and LTD | $375,817.00 | 2009 | 2R01NS047384-06