Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo study  

Fragile X syndrome (FraX, also FXS) is the most common known heritable cause of human intellectual disability. Though recent research has revealed much about the genetic and neurobiological bases of FraX, knowledge about specific and effective treatments for affected individuals is lacking. Based on information from both human and animal studies, one cause of intellectual disability in FraX may be related to deficits in a particular brain neurotransmitter system (the "cholinergic" system). Thus, this study will use a specific medication, donepezil, to augment the cholinergic system in adolescents affected by FraX. If found to be effective, the knowledge generated by this research may also be relevant to other developmental disorders that share common disease pathways with FraX. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $240,000.00
Current Award Period 2009-2012
Project Number 5R34MH085899-02
Principal Investigator Reiss, Allan
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo study (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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