Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Proteomics in drosophila to identify autism candidate substrates of UBE3A  

Angelman syndrome (AS) is a rare and severe developmental disorder caused by maternal duplications of the region containing the gene UBE3A. AS patients make up 3% of all autism cases. Using the powerful genetic model organism Drosophila (fruit fly), the researchers will identify proteins regulated by UBE3A and investigate the possibility that these proteins are also dysregulated or mutated in some cases of autism. Understanding how increased levels of UBE3A result in an autism phenotype at the molecular level could help researchers better identify and treat autism. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $316,355.00
Current Award Period 2008-2012
Project Number 5R01NS059902-03
Principal Investigator Reiter, Lawrence
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of Tennessee Health Science Center
State/Country Tennessee
Web Link 1 Proteomics in drosophila to identify autism candidate substrates of UBE3A (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Proteomics in Drosophila to identify autism candidate substrates of UBE3A | $319,550.00 | 2009 | 5R01NS059902-02
Proteomics in Drosophila to identify autism candidate substrates of UBE3A | $313,338.00 | 2008 | R01NS059902-01A2
Proteomics in Drosophila to identify autism candidate substrates of UBE3A (supplement) | $10,000.00 | 2009 | 3R01NS059902-02S1